Overview Alzheimer's-Cognition and Vitamin D FACT: Cognitive decline is 19X more likely if low vitamin D FACT: Dementia is associated with low vitamin D levels. FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022 FACT:
Vitamin D3 is special among all nutrients in that the great majority of the populations of all countries ingest, or produce in their skin, only a fraction of what they need to run their immune systems properly.
There is a stark relationship between even lower than the lousy average level of 25-hydroxyvitamin D (which is made primarily in the liver from vitamin D3, and is the compound the kidneys and immune system need) and risk of neurodegeneration. This is known from numerous lines of research, especially concerning Parkinson's disease and multiple system atrophy, which are essentially the same disease, with dementia with Lewy bodies, in that they all involve the self-catalysed, prion-like, misfolding of the same protein.
The average daily supplemental amount of vitamin D3 is specified as ranges of ratios of body weight, with higher ratios for people suffering from obesity. This is because obesity reduces the ability of the liver (primarily) to hydroxylate vitamin D3 in to 25-hydroxyvitamin D while the excess adipose (fatty) tissue absorbs both compounds: https://vitamindstopscovid.info/00-evi/#obesity-deficit .
These recommendations are intended to ensure that all, or almost all, people who follow them will safely attain, after several months) at least the 50 ng/mL 125 nmol/L circulating level of 25-hydroxyvitamin D, which the immune system needs to function properly. These recommendations are for people of all ages and body weights for whom there is no medical advice to the contrary.
Vitamin D3 is special among all nutrients in that the great majority of the populations of all countries ingest, or produce in their skin, only a fraction of what they need to run their immune systems properly.
There is a stark relationship between even lower than the lousy average level of 25-hydroxyvitamin D (which is made primarily in the liver from vitamin D3, and is the compound the kidneys and immune system need) and risk of neurodegeneration. This is known from numerous lines of research, especially concerning Parkinson's disease and multiple system atrophy, which are essentially the same disease, with dementia with Lewy bodies, in that they all involve the self-catalysed, prion-like, misfolding of the same protein.
See the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/#3.3, especially Ogura et al. 2021: https://www.sciencedirect.com/science/article/pii/S2405650221000617 .
For how much vitamin D3 to take, see the recommendations of New Jersey based Professor of Medicine, Sunil Wimalawansa, at: https://vitamindstopscovid.info/00-evi/#00-how-much and https://nutritionmatters.substack.com/p/how-much-vitamin-d3-to-take. These are his recent slight simplification of recommendations in his 2022 Nutrients article: https://www.mdpi.com/2072-6643/14/14/2997 .
The average daily supplemental amount of vitamin D3 is specified as ranges of ratios of body weight, with higher ratios for people suffering from obesity. This is because obesity reduces the ability of the liver (primarily) to hydroxylate vitamin D3 in to 25-hydroxyvitamin D while the excess adipose (fatty) tissue absorbs both compounds: https://vitamindstopscovid.info/00-evi/#obesity-deficit .
These recommendations are intended to ensure that all, or almost all, people who follow them will safely attain, after several months) at least the 50 ng/mL 125 nmol/L circulating level of 25-hydroxyvitamin D, which the immune system needs to function properly. These recommendations are for people of all ages and body weights for whom there is no medical advice to the contrary.
Thanks for all your work. I just got back my D level and it's 130 on 50,000 IU 3 x per week. Perfect!