Overview Alzheimer's-Cognition and Vitamin D

Overview Alzheimer's-Cognition and Vitamin D

• FACT: Cognitive decline is 19X more likely if low vitamin D

• FACT: Dementia is associated with low vitamin D levels.

• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022

• FACT: Dementia is associated with low vitamin D - many studies

• FACT: Alzheimer's Disease is 4X less likely if high vitamin D

• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels

• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)

• OBSERVATION: Reports of increased vitamin D levels result in improved cognition

• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012

• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.

• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D

• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018

• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D

• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D

• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways

• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D

• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily

• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X

• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org

• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence

• FACT: Vitamin D is extremely low cost and has very very few side effects

• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D

A summary of the key points of this page by Claude2 - July 2023

The PDF provides an overview of the evidence linking vitamin D deficiency to increased risk of Alzheimer's disease and cognitive decline. It highlights numerous studies, facts, and observations supporting vitamin D's role in brain health.

Some key facts presented:

• Cognitive decline is 19 times more likely with low vitamin D levels.

• Dementia and Alzheimer's disease are consistently associated with low vitamin D in many observational studies.

  • Alzheimer's is 2.3 times more likely in the elderly with low D.

• Every single risk factor for Alzheimer's disease is also a risk factor for low vitamin D.

• As vitamin D levels in the elderly continue to decline, cognition gets worse.

• Increasing vitamin D has been observed to improve cognition in some reports.

• Alzheimer's patients are 3 times more likely to have a malfunctioning vitamin D receptor gene which can prevent vitamin D from getting into cells.

Some key observations:

• In animal studies, vitamin D has been found to help remove amyloid brain plaque associated with Alzheimer's.

• Exposure to DDT, which decreases vitamin D, increases Alzheimer's risk by up to 3.8 times.

• Genes linked to Alzheimer's all also restrict vitamin D function.

• There are at least 11 ways vitamin D may help reduce Alzheimer's disease risk and pathology.

• Daily vitamin D supplementation around 4,000 IU improved cognition in Alzheimer's patients in a clinical trial.

In summary, the PDF compilation of references indicates substantial evidence for a link between low vitamin D and increased Alzheimer's and cognitive decline. It advocates vitamin D supplementation as a low-risk, low-cost prevention and treatment strategy. Combining vitamin D with omega-3 is highlighted as another promising approach currently being tested.