Which cancers appear to be prevented or treated by vitamin D

Based on 2 pages from VitaminDWiki

Major Cancers with Strong Evidence:

1. Colorectal Cancer
   25% less likely with good vitamin D levels
   Death from colon cancer 8X less likely with good vitamin D levels
   Multiple meta-analyses show preventive effects

2. Breast Cancer
   Risk decreased 16% for every extra ng of vitamin D
   Mortality reduced 60% with vitamin D levels above 60 ng/mL
   Treatment outcomes improved with vitamin D supplementation

3. Prostate Cancer
   Death 40% less likely with vitamin D levels above 40 ng/mL
   Risk cut in half by consuming vitamin D along with other nutrients
   Treatment effectiveness enhanced with vitamin D

4. Lung Cancer
   Death rates 40-60% lower with high vitamin D levels
   Risk decreases 5% for every 2.5 ng increase in vitamin D
   Up to 7X more deadly if poor vitamin D genes

5. Melanoma/Skin Cancer
   25X more likely with low vitamin D
   Better survival rates with higher vitamin D levels
   Particularly strong connection with UV exposure and vitamin D production

Other Cancers with Evidence of Benefit:

• Pancreatic Cancer (55% less likely with optimal vitamin D)

• Bladder Cancer (60% less likely with high vitamin D)

• Lymphoma (survival rates improved with adequate vitamin D)

• Ovarian Cancer (37% less likely with high vitamin D)

• Liver Cancer (30% less risky with vitamin D above 30 ng/mL)

Key Points:
Prevention typically requires 2,000-5,000 IU of vitamin D daily
Treatment may need >8,000 IU daily
Blood levels above 40-60 ng/mL appear optimal for cancer prevention
Vitamin D works through multiple mechanisms to fight cancer:

• Inhibits cancer cell growth

• Reduces metastasis

• Stimulates cell differentiation

• Induces cancer cell death

• Prevents tumor blood vessel formation

• Reduces inflammation

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Overview Cancer and vitamin D