Magnesium Matters in health and disease – Review Oct 2024

Magnesium Matters in health and disease – Review Oct 2024

Summary by Perplexity AI Dec 2024

This comprehensive review examines the vital role of magnesium (Mg) in human health and disease.
Here are the key findings:
Physiological Functions
Mg serves as an essential mineral involved in over 300 enzymatic reactions
It plays critical roles in:

• Energy metabolism and ATP production

• Muscle contraction and relaxation

• Protein synthesis

• DNA/RNA synthesis

• Cellular signaling

• Ion transport across cell membranes

Health Implications
Cardiovascular Health
Mg helps regulate blood pressure and heart rhythm by acting as a natural calcium channel blocker. Adequate Mg levels are associated with reduced risk of hypertension and cardiovascular diseases.
Metabolic Health
Mg deficiency is linked to insulin resistance and type 2 diabetes development. It helps regulate glucose metabolism and improves insulin sensitivity.
Bone Health
The mineral is crucial for bone formation and mineralization
. Low Mg intake is associated with decreased bone mineral density and increased osteoporosis risk
.Muscle Function
Mg regulates muscle contraction/relaxation and energy production
. Deficiency can lead to muscle weakness, cramps, and impaired performance
.Mental Health
Research suggests Mg deficiency may be associated with anxiety, depression, and other psychiatric disorders
. Supplementation shows promise in improving mental well-being.
Clinical Applications
Recommended Intake

• Adult men: 400-420 mg/day

• Adult women: 310-320 mg/day

Supplementation Benefits

• May improve cardiovascular outcomes

• Can enhance insulin sensitivity

• Shows potential in treating migraines

• May help with muscle recovery

• Could support bone health

• May improve mental health symptoms

Risk Factors for Deficiency

• Poor dietary intake

• Aging

• Certain medications

• Medical conditions affecting absorption

• Excessive urinary losses

The review emphasizes the importance of maintaining adequate Mg levels through diet or supplementation for optimal health outcomes

VitaminDWiki – Overview Magnesium and vitamin D has a Venn diagram

VitaminDWiki – Magnesium and Vitamin D contains

369items in category, see also

• Overview Magnesium and vitamin D

• Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023

• The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023

• Magnesium deficiency – causes and symptoms – May 2016

• Magnesium Depletion Score predicts increased risk of various health problems

• Vitamins and Metals needed by the Immune System – Jan 2020

• Magnesium: intake decreased, difficult to measure in body – Sept 2018

• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019

• Magnesium fights diabetes (yet again)– meta-analysis Nov 2021

• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017

• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019

• Magnesium is important for health but levels are low – July 2018

• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol

• Magnesium etc. reduced in crops (must supplement) – 2009

Magnesium and Vitamin D

• Intracellular Magnesium and Vitamin D - a few studies

• Vitamin D and Magnesium need each other - many studies

• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019

• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020

• Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018

• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018

• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017

• Vitamin D Cofactors in a nutshell

• Magnesium and Vitamin D - similar, different and synergistic